Side Effects and Conditions Caused By Isotretinoin

Minor discomforts such as dry mouth or nose, dry eyes, dry skin, or itching usually go away as the body adjusts to the drug and do not require medical attention unless they continue or are bothersome.

Other side effects should be brought to a physician’s attention. These include:
•    burning, redness, or itching of the eyes
•    nosebleeds
•    signs of inflammation of the lips, such as peeling, burning, redness or pain

Bowel inflammation is not a common side effect, but it may occur. If any of the following signs of bowel inflammation occur, stop taking isotretinoin immediately and check with a physician:
•    pain in the abdomen
•    bleeding from the rectum
•    severe diarrhea

Conditions Caused By Benzoyl Peroxide and Tretinoin

The most common side effects of antiacne drugs applied to the skin are slight redness, dryness, peeling, and stinging, and a warm feeling to the skin. These problems usually go away as the body adjusts to the drug and do not require medical treatment.
Other side effects should be brought to a physician’s attention. Check with a physician as soon as possible if any of the following side effects occur:

•    blistering, crusting, or swelling of the skin
•    severe burning or redness of the skin>
•    darkening or lightening of the skin (This effect will eventually go away after treatment with an antiacne drug ends.)
•    skin rash

Other side effects are possible with any type of antiacne drug. Anyone who has unusual symptoms while using antiacne drugs should get in touch with his or her physician.
Interactions

Patients using antiacne drugs on their skin should tell their physicians if they are using any other prescription or nonprescription (over-the-counter) medicine that they apply to the skin in the same area as the antiacne drug.

Isotretinoin may interact with other medicines. When this happens, the effects of one or both drugs may change or the risk of side effects may be greater. Anyone who takes isotretinoin should let the physician know about all other medicines being used and should ask whether the possible interactions can interfere with drug therapy.

Among the drugs that may interact with isotretinoin are listed below:
•    Etretinate (Tegison), used to treat severe psoriasis. Using this medicine with isotretinoin increases side effects.
•    Tretinoin (Retin-A, Renova). Using this medicine with isotretinoin increases side effects.
•    Vitamin A or any medicine containing vitamin A. Using any vitamin A preparations with isotretinoin increases side effects. Do not take vitamin supplements containing vitamin A while taking isotretinoin.
•    Tetracyclines (used to treat infections). Using these medicines with isotretinoin increases the chance of swelling of the brain. Make sure the physician knows if tetracycline is being used to treat acne or another infection.

Parental Concerns

Acne comes at a difficult time, the adolescent years. While mild acne can be treated with over-the-counter medications, more severe acne needs medical attention. Experts advise against a wait-and-see attitude. Treatment options can help control acne and avoid scarring.

Isotretinoin can cause serious birth defects, including mental retardation and physical deformities. This medicine should not be used during pregnancy. Sexually active adolescent females who are able to bear children should not use isotretinoin unless they have very severe acne that has not cleared up with the use of other antiacne drugs. In addition, acne treatments that can dry the skin should be used with caution by people with skin of color.

Maintaining Healthy Skin

The skin serves numerous functions - detoxifying, protecting, regulating - but the primary protective or barrier function is the most obvious. The top layer of skin cells has the most important function in maintaining the effectiveness of the barrier. Here the individual cells overlie each other and are tightly packed, preventing bacteria from entering and maintaining the water-holding properties of the skin.
Fatty substances (lipids) are secreted by the cells during the course of their journey from the base layer of the skin to the top. These lipid molecules join up and form a tough connecting network, in effect acting as the mortar between the bricks of a wall.

The cell wall barriers are simply layers of fats that surround the watery contents. Therefore, the communication mechanisms must operate through these fatty cell walls. In fact, many of the substances that are involved in this communication process are various fats since it is easiest for fats to move within the fatty layers that comprise the cell walls. Despite its bad reputation, proper fats and cellular fats are of major importance in our body’s biochemistry and physiology.

Damage to the skin barrier can result from a combination of genetic predisposion and exposure to sensitizing chemicals and other substances. That is why avoiding irritants is as important as using products that help. In skin care, the most common irritants are usually perfumes and preservatives.

Fatty substances control the majority of our body’s physiology through receptors that activate many important genes. Likewise, our skin barrier is comprised of a supporting structure of collagen, a protein that contains fats that serve a critical function. These fats prevent the excess loss of water through our skin and prevent the cells of our body from becoming dehydrated and dying.

A major sign of a defective skin is the dryness that results from excessive water loss. This water can not be applied topically but must be ingested. To prevent the excessive water loss and the resulting dry skin, we must repair the skin barrier. We find that the skin composition in individuals with dry skin is due to an improper mixture of the skin fats. This is commonly due to a deficiency in our diet of the correct fats, those contained in natural olive oils, avocados, and healthy nuts, etc. On a nutritional basis, we can provide these necessary fats through the skin sometimes through topical treatments containing natural butters or oils, like Shea, olive and cocoa butter. The epidermis is not a usual means to acquire nutrition but it can absorb enough fatty substances to correct the fat imbalances that are the cause of the defect in the skin’s barrier function and thus correct the dry, itchy skin or sensitive skin problem. Try to be aware of chemical preservatives in any topical products you do use.

Although many products today are labeled “fragrance free,” that is really a misnomer. Nearly all products contain some fragrance to mask their chemical odor; so-called fragrance-free products may just contain fewer chemicals than others. What’s more, the fragrances used in many products (even pricey perfumes) are commonly synthetic. For sensitive individuals, this chemical brew can be a problem To make matters worse, many natural fragrances are now extracted using harsh solvents rather than old-fashioned distillation methods, in which fewer chemicals come into contact with the essential oil of the flower. Unless you can determine the extraction method used, be cautious. This is one reason many individuals react negatively to the essential oils used in aromatherapy massages and related products – many are of a synthetic, chemical composition.

According to several studies, various preservatives including formaldehyde, parabens, and others commonly used in skin, hair, and beauty products can also provoke allergic reactions. Although the preservatives are needed to maintain product shelf life and only minute amounts are present in any given product, many products contain these same chemicals, including skin care products, makeup, medications, antiperspirants, toothpaste, and foods. Many of these products are used on a daily basis, causing a higher reaction rate. As a result, the overall exposure to these harmful ingredients is higher than would occur if only a single product were used. Studies show that massage therapists have more contact dermatitis – or skin inflammation - due to exposure to these extracts.

Until recently, few studies investigated the cumulative impact of repeated exposures to preservatives in a variety of products and ingredients. For the majority of people, these product preservatives are an additional benefit, not a problem. But, as the chemical compositions increase, so do the allergic reactions.
If you suffer from sensitive, allergic skin or severe dry skin, you may be among those who will have a problem or reaction to these chemical-laden products. In this case, it is your role as an informed consumer to carefully read labels for all products that come into contact with your skin - internally or externally- to assure that they don’t contain the listed ingredients that you must avoid. Your skin barrier does a lot to protect you naturally, help it out when you can and feed it nourishing chemical-free products whenever you can.

SKIN HYDRATION: OILY VS. DRY

With oily skin, your face may often look shiny, and you naturally avoid products that feel oily. You’ll be more vulnerable to acne and breakouts than dry skin types. People with dry skin will notice that their skin feels dry and has a dull color and/or rough texture.

Oil Production

The skin has many oil (sebaceous) glands, which secrete oil that contains wax esters, triglycerides, and squalene. These fats (or lipids) form a film that helps keep moisture in the skin. While increased sebum production results in oily skin, the opposite is not always the case, as dry skin can also arise from an impaired skin barrier. Oil production can be affected by diet, stress, and hormones-as well as genetics. In a study of twenty pairs each of identical and nonidentical same-sex twins, identical twins had virtually identical amounts of oil production, while the nonidentical twins had significantly different amounts.

Dryness and oiliness depend primarily on the condition of the skin barrier, the outer layer of skin which helps the skin retain moisture, and the oil (sebum) production itself. The barrier is like a brick wall, with each brick (or cell) held in place by mortar (fats called lipids). Harmful ingredients, cold, and dry weather can wear down these fats, eroding the mortar so that the “bricks” are not secured in their proper place. A variety of outside agents, including detergents, acetone, chlorine and other chemicals, and even prolonged water immersion can harm the barrier, or the barrier may be deficient for genetic reasons.

The barrier’s main components are ceramides, fatty acids, and cholesterol, all different kinds of lipids. These must be present in the right proportion to keep the skin watertight. An impaired barrier will tend toward both dryness and sensitivity. Dryness results when skin moisture evaporates. Sensitivity results when a deficient barrier permits the entry of outside irritants.

Repairing the skin barrier with the right skin care products will help treat a variety of skin conditions. Incorporating key dietary nutrients, such as essential fatty acids and cholesterol, provides the necessary building blocks. Nutrient deficiencies can weaken your skin’s ability to repair and rebuild, which is why people who take cholesterol-lowering drugs often have dry skin.

Helpful Hints to Heal Acne

While we all wish to have perfect skin, some days are more important than others - whether it’s a job interview, an important date, or a social gathering where you may be introduced to many new people, looking our best during these special occasions is usually a priority. While acne should be the last thing on our minds, many times the additional stress brought on by these very important occasions can result in just that – unwanted acne.

If you have ever awakened to a big day only to find a BIG SPOT where it shouldn’t be, read the below tips to help prevent and heal acne more regularly to help avoid those nasty last minute acne issues.

Acne Tip #1

Drink plenty of water – plain and simple. This is probably one of the best ways to prevent future acne. Doctors recommend this easy exercise to remember – whatever your body weight is in pounds, divide that number by two to get the number of ounces of water you should consume for optimal skin flushing and overall health. Add a slice of lemon juice to further enhance the cleansing effects. Your goal is to flush all the toxins in your body and cleanse your skin from inside out. This will also help your body run smoothly by cleaning out unnecessary toxins that help build bacteria onto your skin.

Acne Tip #2

Resist the urge to pop - popping your pimples incorrectly is something you don’t want to do. There are dermatologist recommendations how to do this properly, but most folks want the offending item removed much earlier than it is safe to do so. While it can be a quick fix to your acne, the incorrect action could result in a scar that could become very noticeable if you make a habit of popping. Even worse, most dermatologists tell us the majority of the plugged oil creating the acne goes back into the underlying skin layer, which will reform as more acne later. If you really need to pop, try to follow a safe procedure.

Acne Tip #3

Change your bed linens regularly –changing your linens weekly is ideal. Repeatedly placing your skin on the surface of a pillow or sheet will allow bacteria and oil to build up, creating an environment for further outbreaks.

Following these simple actions can help tremendously when it comes to having acne free skin.